PROAKAP4 - Antibodies & ELISA Kits
Male Fertility & Semen Quality Biomarker
proAKAP4 as a biomarker has been described for years in male fertility dysfunction studies. Any modification of proAKAP4 expression during spermatogenesis or modification in its metabolism will have consequences on sperm motility, hyper motility, sperm capacitation and then fertility (Delehedde et al., 2019). Measuring expression and levels of concentrations of proAKAP4 in semen appears today an interesting approach to evaluate semen quality in males infertility disorders.
In mammals, proAKAP4 and AKAP4 are both specifically localized to the fibrous sheath of the principal piece of the flagellum and are largely known to be involved in the flagellum structure and sperm motility (Sergeant et al., 2019)
4BioDx offers ready-to-use ELISA kits and Antibodies for quantitative detection and analysis of proAKAP4/AKAP4 in farm animals, lab animals, companian animals and in humans. All products are for Research Use Only.
Assay Applications :
SPERM SELECTION :
Selecting semen before cryopreservation / predict post-thaw motility
SPERM QUALITY CONTROL :
A functional approach in semen analysis and fullfilling the need for control quality.
IMPROVING SPERM CRYOSTORAGE VIABILTY :
Predicting shelf life of Chilled Semen
Selecting the right Extenders for better cryopreseravtion & recovery
Articles & Publications
General Articles
ProAKAP4 protein marker: towards a functional approach to male fertility.
The sperm specific protein proAKAP4 as an innovative marker to evaluate sperm quality and fertility.
Concentration of proAKAP4 as a pertinent read-out of sperm quality in mammals.
Investigating proteomic methods and tools to assess sperm quality.
Pig / Swine
Bull / Bovine
The proAKAP4 concentrations in Nelore bull sperm and their relation to FTAI conception rate results
Quality assessment of frozen bull semen with the precursor A-kinase anchor protein 4 biomarker
ProAKAP4 concentrations in semen as a predictive tool of bull fertility: A preliminary study.
Horse / Equine / Stallion
Characterization of proAKAP4 expression, metabolism and localization in Equus asinus spermatozoa
ProAKAP4 correlation with motion parameters and spermatozoa subpopulations in stallion
Mass spectrometry reveals distinct proteomic profiles in high- and low-quality stallion spermatozoa.
Canine / Dog
Variation of ProAKAP4 concentration among different ejaculates from the same dogs
Are AKAP4 and proAKAP4 Found in Canine Semen? Preliminary Results.
ProAKAP4 as a valuable marker to assess sperm quality in dogs.
Expression of proAKAP4 in dog semen as promising marker of sperm quality.
Ram
Human
A Kinase Anchor Protein 4 is vulnerable to oxidative adduction in male germ cells.
ProAKAP4 polypeptide as a biomarker of sperm functionality and male fertility disorders.
Rodents
Influence of sperm cryopreservation on sperm motility and proAKAP4 concentration in mice
PRSS50 is a testis protease responsible for proper sperm tail formation and function.